Spatial DNA Methylation Available in 2026

Map DNA methylation in tissue, with spatial precision

A next-generation assay that localizes methylation patterns directly in tissue sections—enabling multi-omic context, cell-type resolution, and disease-relevant insights you can’t get from bulk or dissociated methods.

Single-slide workflow Tissue-native context Multi-omics compatible
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Spatial DNA methylation assay concept image

AGBT 2026 Poster

Spatial ATAC-TAPS+ integrates chromatin accessibility and DNA methylation profiling in a single tissue section, resolving epigenetic heterogeneity that bulk methods miss.

New Research

Spatial ATAC-TAPS+: Co-Registered Accessibility & Methylation Profiling

Presented at AGBT 2026 — the first spatial method to simultaneously map open chromatin and base-resolution DNA methylation across intact tissue architecture.

  • 27,923 clustered nuclei at 10 µm resolution
  • 8 distinct epigenetic compartments in human medulloblastoma
  • 2,195 differentially methylated genes identified
  • TAPS+ conversion preserves ATAC library quality
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Spatial ATAC-TAPS+ poster preview

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Info@atlasxomics.com

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C/O John B. Pierce Laboratory
290 Congress Ave.
New Haven, CT 06519-1403

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