Map DNA methylation in tissue, with spatial precision.
Profile 5mC and 5hmC at CpG sites directly in intact tissue — with cell-type resolution and spatial context. Co-profile chromatin accessibility in the same section using ATAC + TAPS.
single run
Spatial methylation profiling in intact tissue
The AtlasXomics spatial DNA methylation platform uses TAPS+ chemistry — a bisulfite-free, base-resolution approach — to read 5mC and 5hmC directly on tissue sections. Pair it with ATAC in the same run to simultaneously map chromatin accessibility and methylation state.
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ATAC + TAPS: chromatin accessibility and methylation, same section The primary offering co-profiles open chromatin and CpG methylation from a single tissue section — directly linking regulatory state to methylation without serial sectioning.
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Base-resolution 5mC / 5hmC at CpG sites TAPS+ is non-destructive and bisulfite-free — preserving DNA integrity while delivering high conversion efficiency and low background.
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Tissue-native spatial context Resolve methylation heterogeneity across cell populations, tissue zones, and tumor microenvironments — without dissociation or cell sorting.
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DMNT mode coming 2027 DMNT dissolves histones to expose the full genome for genome-wide methylation profiling — paired with spatial transcriptomics in a single run for unparalleled multi-omic coverage.
AGBT 2026 Poster — Spatial ATAC-TAPS+
The first spatial method to simultaneously map open chromatin and base-resolution DNA methylation across intact tissue — demonstrated in human medulloblastoma.
- 27,923 clustered nuclei at 10µm resolution
- 8 distinct epigenetic compartments in human medulloblastoma
- 2,195 differentially methylated genes identified across clusters
- TAPS+ conversion preserves ATAC library quality in co-profiling
Ready to explore spatial methylation?
We're inviting research collaborators for early access evaluation of ATAC + TAPS co-profiling. Our team will help you design an experiment around your tissue type and biological question.
