AGBT 2026 — New Research
Integrating Spatial Open Chromatin & DNA Methylation Profiling with Spatial ATAC-TAPS+
Co-registered chromatin accessibility and DNA methylation mapping in a single tissue section — resolving epigenetic heterogeneity that bulk methods miss.
27,923
Clustered nuclei at 10 µm resolution
~8,226
Median fragments per spot
8
Distinct epigenetic compartments resolved
2,195
Differentially methylated genes identified
Key Findings
Dual-Modality in One Section
TAPS+ conversion preserves spatial ATAC library integrity — fragment size distribution, FRiP, and TSS enrichment remain stable before and after conversion.
Spatial Regulatory Compartments
Unsupervised clustering identifies eight spatially coherent epigenetic compartments with coordinated accessibility–methylation divergence across tumor regions.
Interpretable Chromatin States
Integrated accessibility and 5mC define four functional chromatin states — active, poised, repressed, and latent — enabling direct biological interpretation.
Spatial ATAC-TAPS+ Workflow
Step 1
Tn5 In Situ Tagmentation
Step 2
Microfluidic Spatial Barcoding
Step 3
Tissue Imaging & Co-Registration
Step 4
TAPS+ Conversion (5mC/5hmC)
Step 5
Library Prep & Sequencing
Step 6
Dual-Modality Spatial Maps