YianXing’s team presents Spatial-DMT, a method for co-mapping DNA methylation and gene expression in tissue sections at near single-cell resolution. It reveals spatially coordinated epigenetic regulation during mouse development.

The Gallo lab used spatial ATAC-seq at 25 µm resolution, combined with spatial multi-omics and snATAC on 28 IDH-wild-type glioblastoma resections, to reveal a consistent layout where small SOX10-high oligodendrocyte-progenitor-like “islands” are nested within broader VEGFA-high mesenchymal-like sheets in 27 of 28 tumours.

The Deng Lab finds Spatial FFPE-ATAC-seq shows that chromatin accessibility mapping in archived FFPE blocks is finally feasible—signaling the next frontier for spatial epigenomics

Dr. Chi-Ming Li’s built 20 µm-pixel chromatin maps of IL-2-treated mouse spleen and lung, pinpointing activated regulatory T-cell niches and showing BATF/BACH1 bZIP motifs opening

Chromatin accessibility in human dorsal root ganglia is sex-dimorphic

Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer’s disease mouse brain using Spatial ATAC-Seq

High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq

High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq

High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq

Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes