Spatial Multi-Omics with Cellular Resolution

Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues

Deng lab demonstrates spatial FFPE-ATAC with DBiT-seq, mapping chromatin accessibility in archived brain, thymus, and melanoma blocks at 10 µm resolution.

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Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer’s disease mouse brain

AtlasXomics spatial ATAC-seq charts chromatin landscapes in AD-model mouse brains, uncovering microglia- and astrocyte-specific accessibility shifts tied to neuro-inflammation and synaptic dysfunction.

Spatial epigenomic niches underlie glioblastoma cell state plasticity

Spatial ATAC at 25 µm, combined with multi-omics and snATAC across 28 GBM resections, reveals a consistent layout with SOX10-high OPC-like “islands” nested within the tumor microenvironment.

Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes

Spatial ATAC-seq of human DRG uncovers X-linked EGR-motif enhancers enriched in female neurons and AP-1-driven Ca²⁺ pathways in males, outlining sex-specific pain signaling programs.

Basic-Leucine-Zipper Transcription Factors Regulate Selective Molecular Phenotypes in Regulatory T Cells During IL-2-Induced Activation

Spatial ATAC-seq at 20 µm pinpoints activated Treg niches in spleen and lung, with BATF/BACH1 motifs opening at sites matching Th-like phenotypes observed in bulk and single-cell data.

Spatial profiling of chromatin accessibility in mouse and human tissues

Spatial-ATAC-seq combines in situ Tn5 chemistry with deterministic barcoding to map accessible chromatin and gene regulators across embryos, brain, and lymphoid tissues.

Spatial-CUT&Tag: Spatially resolved chromatin modification profiling at the cellular level

Spatial CUT&Tag integrates in situ chemistry, microfluidic barcoding, and NGS to profile histone modifications across tissues and derive single-cell epigenomes in situ.