Uncover chromatin
accessibility with
spatial precision.
Map open chromatin directly on tissue — no dissociation required. Connect regulatory programs to morphology and cell state on the same slide.
PLATFORM SPECS
SPOTS PER CHIP
48,400+
RESOLUTION
10 × 10 µm
SAMPLE COMPATIBILITY
FF & FFPE
MULTI-OMIC CAPABILITY
ATAC · RNA
Methylation
Methylation
01 — Technology
Spatial ATAC-seq for high-resolution chromatin accessibility
Preserve spatial organization while profiling chromatin accessibility across tissue sections. Connect accessibility to morphology, cell state, and regulatory programs — all on the same slide.
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Whole-tissue context No dissociation required. Spatial organization is preserved so you can correlate accessibility with histology.
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From peaks to programs Call peaks, quantify gene activity, score motifs and TF binding potential, and annotate neighborhoods and cell states in a single workflow.
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Seamless co-analysis Designed to integrate with spatial RNA, spatial DNA methylation, or H&E for multi-omic interpretation and better target discovery.
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FFPE support (new) Run challenging archival samples with an FFPE-ready workflow and analysis presets.
Protocol Overview
DBit-seq workflow for spatial ATAC
Example Data · Stomach Tissue
Spatial chromatin accessibility maps
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02 — Technology Publications
The methods and platform behind spatial ATAC-seq.
These publications showcase spatial ATAC-seq across fresh frozen and FFPE tissues, demonstrating how the assay maps chromatin accessibility within tissue architecture to reveal spatially organized cell states, regulatory programs, and disease-associated epigenetic changes.
Nature Communications Manuscript 2026
FFPE ATAC
Spatially decoding genotype-associated epigenetic landscapes in human lymphoma FFPE tissues via epi-Patho-DBiT
epi-Patho-DBiT enables spatial profiling of chromatin accessibility and histone modifications directly from FFPE lymphoma tissues using spatial FFPE-ATAC-seq and spatial FFPE-CUT&Tag. Applied to B-cell lymphoma samples, the platform reveals tumor-specific epigenetic states, copy number alterations, spatial tumor dynamics, and regulatory changes associated with malignant transformation.
Nature Communications 2025
FFPE ATAC
Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues
Spatial FFPE-ATAC-seq enables high-resolution chromatin accessibility profiling directly from archived FFPE tissues while preserving spatial tissue architecture. By overcoming fixation-related barriers, this methodology unlocks FFPE sample archives for spatial epigenomic discovery across normal and diseased tissues, including tumor microenvironments.
Nature 2022
FF ATAC
Spatial profiling of chromatin accessibility in mouse and human tissues
Spatial ATAC-seq enables genome-wide chromatin accessibility profiling directly within tissue sections, preserving the spatial context of cell types, states, and regulatory programs. By combining in situ Tn5 transposition with microfluidic spatial barcoding, the method reveals tissue-region-specific epigenetic landscapes across development, brain organization, and immune microenvironments.
03 — Select Application Publications
Select application studies across oncology, neurodegeneration, and sensory biology.
A curated set of studies applying spatial ATAC-seq to diverse biological questions — from tumor cell state plasticity to sex-linked epigenomic differences in human tissue.
bioRxiv 2025
Glioblastoma
Spatial epigenomic niches underlie glioblastoma cell state plasticity
Reports spatially nested tumor niches in IDH-wildtype GBM and shows how local and long-range signals align with chromatin accessibility states to drive plasticity.
bioRxiv 2025
Alzheimer's
Spatial profiling reveals chromatin alterations in glial cells in Alzheimer's disease mouse brain
Spatial ATAC-seq in 5xFAD vs. control charts accessibility shifts in microglia and other glia, linking motif programs to AD-related chromatin changes.
PAIN 2025
Human DRG
Epigenomic landscape of human dorsal root ganglion: sex differences and nociceptive gene regulation
Bulk and spatial ATAC-seq reveal sex-linked accessibility differences in human DRG, including X-chromosome–enriched DARs in females.