Bridging Epigenomics and Pathology to Transform Discovery

Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues

Deng lab demonstrates spatial FFPE-ATAC with DBiT-seq, mapping chromatin accessibility in archived brain, thymus, and melanoma blocks at 10 µm resolution.

ASHG 2025 Poster — Unlocking the Spatial Epigenome: Multiomics Platform for Spatial Single-Cell Analysis

Our poster from the American Society of Human Genetics Annual Meeting 2025.

We’ve partnered with 130+ labs worldwide

Explore real datasets, sample outputs, and visualizations from our spatial epigenomics workflows.

Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer’s disease mouse brain

AtlasXomics spatial ATAC-seq charts chromatin landscapes in AD-model mouse brains, uncovering microglia- and astrocyte-specific accessibility shifts tied to neuro-inflammation and synaptic dysfunction.

Spatial epigenomic niches underlie glioblastoma cell state plasticity

Spatial ATAC at 25 µm, combined with multi-omics and snATAC across 28 GBM resections, reveals a consistent layout with SOX10-high OPC-like “islands” nested within the tumor microenvironment.

Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes

Spatial ATAC-seq of human DRG uncovers X-linked EGR-motif enhancers enriched in female neurons and AP-1-driven Ca²⁺ pathways in males, outlining sex-specific pain signaling programs.

Basic-Leucine-Zipper Transcription Factors Regulate Selective Molecular Phenotypes in Regulatory T Cells During IL-2-Induced Activation

Spatial ATAC-seq at 20 µm pinpoints activated Treg niches in spleen and lung, with BATF/BACH1 motifs opening at sites matching Th-like phenotypes observed in bulk and single-cell data.