AtlasXomics Blog

Fresh insights from the spatial epigenome

EpiTrace: A Chromatin Clock to Map Cell Mitotic Age from scATAC‑seq
Atlas Research Spotlights, Aging Atlasxomics Team Atlas Research Spotlights, Aging Atlasxomics Team

EpiTrace: A Chromatin Clock to Map Cell Mitotic Age from scATAC‑seq

EpiTrace turns chromatin accessibility into a “clock,” letting scientists read how many times a cell has divided directly from single-cell ATAC-seq. Trained on ~126 k clock-like loci, the method accurately orders cells by mitotic age across embryos, organoids, and tumors—unlocking barcode-free lineage tracing and spatial maps of cellular aging.

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